TAGMe DNA Methylation Ukufunyaniswa kwePan-cancer
Iimpawu zemveliso
Unyango olungenelelayo kancinci:Khipha ubuncinci be-3mL Igazi le-venous le-peripheral okanye ezinye iindidi ezifanelekileyo zesampulu yeklinikhi
Ukuchaneka:Yamkela idatha enkulu kunye ne-algorithm ye-AI, ukuchaneka kovavanyo≥95%
Ukuguquguquka:Ukufunyaniswa okunye kunokugubungela amathumba ayingozi angama-25 aphezulu.
Inqanaba lokuqala:Ngenelela kuvavanyo lomhlaza kwangethuba, kuyo yonke inkqubo yokuxilongwa kwethumba kunye nonyango.
Uncedo:Yamkela imigangatho yegolide yokufunyanwa kwe-methylation - iteknoloji yokulandelelana kwe-pyrophosphate, inokugqiba uvavanyo kwiiyure ze-4.
Igunya:Ngamalungelo omenzi angama-54 kumazwe ngamazwe nasekhaya, iziphumo zophando ezifanelekileyo ziye zapapashwa kwiCancer Research, Genome Research kunye nezinye iimagazini ezidumileyo kumazwe ngamazwe.
Umgaqo-siseko wokufunyanwa
Ukufunyaniswa komhlaza wonke ziimveliso zovavanyo lweplasma ctDNA methylation eziphuhliswe yi-TAGMe, efuna ubuncinci i-3ml yegazi elipheleleyo ukuze ibambe ngokufanelekileyo kwaye imisele imeko ye-methylation yeendawo ezikhethekileyo zokubeka ze-ctDNA, ukuze kuphunyezwe uvavanyo kwangethuba kunye nokubekwa kweliso okuchanekileyo. yethumba.
Ukusebenza
Ekuqinisekisweni kweesampulu zeklinikhi ezingaphezulu kwama-3000, inqanaba le-methylation ye-TAGMe kwizicubu ze-tumor laliphezulu kakhulu kunelo lezicubu eziqhelekileyo.Ke ngoko, i-TAGMe inokusetyenziswa njengemakishi yomhlaza wepan-pan ekubhaqweni komhlaza ohlukeneyo.
Iijini ezinxulumene ne-Histone zine-hypermethylated kumhlaza wemiphunga kwaye i-hypermethylated HIST1H4F inokusebenza njenge-pan-cancer biomarker.
--- UPhando loMhlaza, UKUBA: 12.7
Njengomakishi womhlaza wepan, i-TAGMe inento ethile ephezulu kunye novakalelo kuqinisekiso lwesampulu yeklinikhi, enexabiso lereferensi eliyimfuneko kuxilongo lwezonyango lwamathumba.
I-TAGMe inobuntununtunu kwiisampulu zethumba ezahlukeneyo xa ubuchwephesha bungaphezulu kwama-95%,
Iimeko zesicelo
Imbali yosapho lomhlaza:Izigulane zomhlaza kwizalamane ezisondeleyo okanye ezizibambiso.
Usulelo lwentsholongwane kunye nezifo ezingapheliyo:Njenge-HPV, i-HBV kunye nolunye usulelo lwentsholongwane, i-polyps yamathumbu, i-atrophic gastritis engapheliyo kunye ne-cirrhosis yesibindi, njl.
Ivezwe kwimeko ye-carcinogenic ixesha elide:Ukuvezwa kwimekobume yemitha okanye iikhemikhali eziyingozi ixesha elide.
Iimpawu ezicingelwayo zethumba:ezifana nokopha okungaqhelekanga kwilungu lobufazi, i-hematochezia, umchamo, amaqhuqhuva emiphunga, ubushushu obuphantsi obungachazwanga okanye ukubhitya, njl.
Imikhwa engalunganga yokuphila ixesha elide: Ukutshaya ixesha elide okanye ukutshaya, ukusela kakhulu, ukutya okutshisayo okanye ukusela okutshisayo, ukutya okunetyuwa eninzi, okucoliweyo, ukungunda, ukutya okutshaywayo kunye nokuqhotsiweyo, njl.
Nika ingqalelo kwiimeko zakho ezisempilweni:ingakumbi kwiqela elineminyaka engaphezu kwama-40
