Isisombululo somhlaza we-endometrial, ukuphelisa umhlaza kwinqanaba lezilonda ze-precancerous.Umhlaza we-Endometrial ngomnye weyona ntlaza mithathu iyingozi kwi-gynecology.
Umhlaza we-Endometrial ngowona mhlaza uxhaphakileyo kwinkqubo yokuzala yabasetyhini, ukwindawo yesibini phakathi kwenkqubo yokuzala yabasetyhini eTshayina, kwaye ixhaphake kakhulu kubasetyhini basezidolophini.Ngokwezibalo ezivela kwi-Arhente yeHlabathi yoPhando kuMhlaza woMbutho wezeMpilo weHlabathi, bekukho malunga nama-420,000 amatyala amatsha omhlaza we-endometrial kwihlabathi liphela ngo-2020, malunga ne-100,000 yokusweleka.
Kwezi meko, malunga nama-82,000 amatyala amatsha omhlaza we-endometrial axelwe e-China, malunga nokusweleka kwe-16,000.Kuqikelelwa ukuba ngo-2035, kuya kubakho iimeko ezintsha ze-93,000 zomhlaza we-endometrial e-China.
Izinga lokunyanga umhlaza we-endometrial wenqanaba lokuqala liphezulu kakhulu, kunye nenqanaba lokusinda leminyaka emi-5 ukuya kuma-95%.Nangona kunjalo, izinga leminyaka emi-5 lokusinda kwisigaba IV somhlaza we-endometrial li-19 kuphela ekhulwini.
Umhlaza we-Endometrial uxhaphake kakhulu kwabasetyhini abasemva kokuya exesheni kunye nabase-perimenopausal, kunye nobudala obuphakathi kweminyaka engama-55.Nangona kunjalo, kwiminyaka yakutshanje, kukho ukuthambekela okukhulayo kwizehlo zomhlaza we-endometrial phakathi kwabasetyhini abaneminyaka engama-40 nangaphantsi.
Okwangoku akukho ndlela efanelekileyo yokuhlola umhlaza we-endometrial
Kwabasetyhini abaneminyaka yobudala, ukuhlolwa kwangaphambili kunye nokulawulwa kwangexesha lomhlaza we-endometrial kunokunyusa ukugcinwa kokuchuma kunye nokubonelela ngethuba lokuphila ixesha elide.
Nangona kunjalo, okwangoku azikho iindlela ezibuthathaka nezichanekileyo zokuhlola umhlaza we-endometrial ekusebenzeni kweklinikhi.Iimpawu ezinjengokopha ngokungaqhelekanga kwilungu lobufazi kunye nokukhutshwa kwelungu lobufazi kumanqanaba okuqala azihoywa lula, nto leyo ekhokelela kuphoswe lithuba lokuxilongwa kwangoko.
Ukuhlolwa kwangaphambili kusetyenziswa imaging ye-ultrasound kunye novavanyo lwesiqhelo lwe-gynecology lunovakalelo oluphantsi.
Ukusetyenziswa kwe-hysteroscopy kunye ne-pathological biopsy i-invasive, kunye ne-anesthesia ephezulu kunye neendleko, kwaye inokubangela ukuphuma kwegazi, ukusuleleka, kunye nokukhutshwa kwe-uterine, okukhokelela kwizinga eliphezulu lokuxilongwa okuphosiweyo, kwaye ayisetyenziswa njengendlela yokuhlola rhoqo.
Isampulu ye-Endometrial biopsy inokubangela ukungonwabi, ukopha, usulelo, kunye nokugqobhozwa kwesibeleko, okukhokelela kwizinga eliphezulu loxilongo oluphosiweyo.
I-TAGMe DNA Methylation Detection Kits (qPCR) ye-Endometrial CancerIsungula iXesha le-Endometrial Cancer Dignosis kunye noNyango 2.0
I-TAGMe DNA Methylation Detection Kits (qPCR) ye-Endometrial Cancerinokuncedisa ngokufanelekileyo ukusilela kwiindlela eziqhelekileyo zokuhlola umhlaza we-endometrial, ukunciphisa kakhulu izinga lokuxilongwa okuphosiweyo kunye nokunceda izigulane zibone iimpawu zomhlaza ngexesha elifanelekileyo.
Uvavanyo oluyimfama kabini "lumgangatho wegolide" wokuqinisekiswa kobugcisa kunye nomgangatho wekliniki i-Epiprobe ehlala ibambelela kuwo!
Iziphumo zovavanyo oluyimfama oluphindwe kabini lubonise ukuba iisampuli ze-scrape yomlomo wesibeleko, i-AUC yayingu-0.86, i-speciality yi-82.81%, kunye ne-sensitivity yi-80.65%;kwiisampuli zebrashi ye-uterine cavity, i-AUC yayiyi-0.83, i-specificity yi-95.31%, kunye ne-sensitivity yayiyi-61.29%.
Kwiimveliso zokuhlola umhlaza kwangethuba, eyona njongo iphambili kukuhlola abantu abanokuba nengxaki kunokuba baxilongwe ngoxilongo.
Kwiimveliso zokuhlola umhlaza kwangethuba, kuthathelwa ingqalelo ukuba injongo yokusetyenziswa komsebenzisi kukuphelisa umngcipheko wokugula kunye nokuphepha uxilongo oluphosiweyo kangangoko kunokwenzeka kokona kunyaniseka okukhulu kubantu abavavanyiweyo.
Ixabiso elibi lokuxela kwangaphambiliI-TAGMe DNA Methylation Detection Kits (qPCR) ye-Endometrial Canceryi-99.4%, nto leyo ethetha ukuba kwinani labantu abafumana iziphumo ezingalunganga, ama-99.4% eziphumo ezibi ziinegative zokwenyani.Ikhono lokuthintela uxilongo oluphosiweyo lubalasele kakhulu, kwaye uninzi lwabasebenzisi abangalunganga banokuqiniseka ukuba akukho mfuneko yokuba bangene kuvavanyo oluhlaselayo ngamazinga aphezulu oxilongo oluphosiweyo.Olu lolona khuselo lukhulu kubasebenzisi.
Ukuzivavanya kwezinto ezinobungozi kumhlaza we-endometrial.
Ngokuphuculwa kwemigangatho yokuphila, izehlo zomhlaza we-endometrial e-China ziye zanda unyaka nonyaka, kwaye kukho umkhwa obhekiselele kwizigulana ezincinci.
Ke, luhlobo luni lwabantu olunokuthi lube nomhlaza we-endometrial?
Ngokuqhelekileyo, abantu abanokuthi babe nomhlaza we-endometrial baneempawu ezintandathu ezilandelayo:
- Unengxaki ye-metabolic syndrome: isifo esibonakaliswa kukutyeba, ngakumbi ukutyeba kakhulu kwesisu, kunye neswekile ephezulu yegazi, iilipids ezingaqhelekanga zegazi, uxinzelelo lwegazi oluphezulu, njl., esichaphazela kakhulu impilo yomzimba;
- Ukuvuselela i-estrogen yexesha elide: ukubonakaliswa kwexesha elide kwi-estrogen eyodwa yokuvuselela ngaphandle kweprogesterone ehambelanayo ukukhusela i-endometrium;
- Ukuqala kokuya esikhathini kunye nokuyeka emva kwexesha: oku kuthetha ukuba inani lemijikelezo yokuya esikhathini liyenyuka, ngoko i-endometrium ibonakaliswe kwi-estrogen stimulation ixesha elide;
- Ukungazali abantwana: ngexesha lokukhulelwa, izinga leprogesterone emzimbeni liphezulu, elinokukhusela i-endometrium;
- Imiba yemfuza: eyona yakudala kakhulu yi-Lynch syndrome.Ukuba kukho iimeko ezincinci zomhlaza wesisu, umhlaza wesisu, okanye izalamane zabasetyhini ezinomhlaza we-ovarian, umhlaza we-endometrial, njl njl phakathi kwezihlobo ezisondeleyo, kufuneka kuqatshelwe kwaye iingcebiso zofuzo kunye novavanyo lungenziwa;
- Imikhwa engafanelekanga yokuphila: njengokutshaya, ukungabikho kokuzivocavoca, kunye nokukhetha ukutya okunekhalori ephezulu kunye nokutya okunamafutha aphezulu okufana neitapile, iifries zasefrentshi, iti yobisi, ukutya okuqhotsiweyo, iikeyiki zetshokolethi, njl. ngakumbi emva kokuwadla.
Unokuzithelekisa kunye neempawu ezi-6 ngasentla ezinokuthi zibe nomhlaza we-endometrial, kwaye uzame ukuzilungisa kangangoko ukuthintela ukusuka kumthombo.
Ixesha lokuposa: May-09-2023